Uji Potensi Antikanker Ekstrak Tiga Spesies Tanaman Sansevieria Dengan Metode Brine Shrimp Lethality Test
DOI:
https://doi.org/10.31851/sainmatika.v17i3.4639Keywords:
anticancer activity, Sansevieria, BSLTAbstract
Indonesia has the potential for abundant natural resources including medicinal plants that have anticancer activity. The aim of this study is to determine the anticancer potential of three Sansevieria plant species extracts using the Brine Shrimp Lethality Test Method. This research is an experimental research method by invitro. Anticancer potency test using the BSLT method on extracts of three species of  lidah mertua leaves consisting of Sansevieria trifasciata, Sansevieria tiger green, and Sansevieria Zeylanica. The results showed that the three species of Sansevieria have potential as anticancer, but the most potential as an anticancer is Sansevieria tiger Hijau because it is very toxic with an LC50 value of 29.646 ppm.
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References
Aliero AA, Jimoh FO, Afolayan AJ. (2008). Antioxidant and antibacterial properties of Sansevieria hyacinthoides. Int. Jor. P. App.Scs. 2:103-110.
Bott, R. (2014). “Data Dan Informasi Kesehatan Situasi Penyakit Kanker.†Igarss 2014 (1):1–5.
Chasanah, U., Rachmawati H., Febriana,V., Wulandari F.T., dkk. (2012). Anticancer Pre-Screening For Several Plant Using Brine Shrimp Lethality Test. Proceeding OfInternational Conference On Drug Development Of Natural Resources. 978-979-18458-5-4.
DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. (2012). Pharmacotherapy:a pathophysiologic Approach 7th Ed. United States (US): McGraw-Hill Companies.
Finney.D.J.(1948). “A Table For The Calculation Of Working Probits And Weight In Probit Analysis. Biometrika. 35(1):191-201
Graidist, Potchanapond, Mananya Martla, and Yaowapa Sukpondma. (2015). “Cytotoxic Activity of Piper Cubeba Extract in Breast Cancer Cell Lines.†2707–18.
Hendrawati, Sri, Ikeu Nurhidayah, and Ai Mardhiyah. (2019). “Self-Efficacy Parents in Undergoing Child Cancer Treatment at the Rumah Kanker Anak Cinta Bandung.†NurseLine Journal 4(1):37.
Kurniawan, H. (2012). Uji Toksisitas Akut Ekstrak Metanol Daun Kesum (Polygonum Minus Huds) Terhadap Larva Artemia salina Leach Dengan Metode Brine Shrimp Lethality Test (BSLT). Skripsi, Universitas Tanjung Pura, Pontianak.
Komala K., Yulia I., Pebrianti R., (2012). Uji Efektifitas Ekstrak Etanol Daun Lidah Mertua (Sansevieria trifasciata Prain) Terhadap jamur (Candida albicans). Fitofarmaka. 2(2): 146-152.
Manullang L., Daniel, dan Enos T. A., (2013), Uji Toksisitas Dan Antioksidan Ekstrak Buah Kelepesoh (Baccaurea Lanceolata (Miq.) Mull.Arg), Journal Science East Borneo,Volume 1 No.1.
Meyer, B.N.,(1982). Brine Shrimp : A Convenient General Bioassay for Active Plant Constituent, Drug Information Journal, Vol. 32.
Pan, L., Chai, H.-B. & Kinghorn, A.D., (2012). Discovery of New Anticancer Agents from Higher Plants. Frontiers in Boscience (Scholar edition), 4, pp.142–156.
Parawansah, Nuralifah, Nurlliyin Akib, and Geong Antrie. (2017). “Uji Toksisitas Akut Ekstrak Etanol Daun Buas-Buas (Premna Serratifolia Linn.) Terhadap Larva Udang (Artemia Salina Leach) Dengan Metode Brine Shrimplethality Test (BLST).†(April):171–77.
Pourfraidon, Z and Sharma, C. (2009). Biological Activity Of Prominent Anti-Cancer Plants Using Brine Shrimp Lethality Test. Journal Of Microbial World. 2(3), 201-204.
Pratama, R. (2010). Potensi Antioksidan Dan Toksisitas Ekstrak Daun Sansevieria cylindrica. Skripsi. Institut Pertanian Bogor Fakultas Matematika dan Ilmu Pengetahuan Alam.
Prawirodiharjo, E. (2014). Uji Aktivitas Antioksidan dan Uji Toksisitas Ekstrak Etanol 70% dan Ekstrak Air Kulit Batang Kayu Jawa (Lanneacoromandelica). Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Syarif Hidayatulloh, Jakarta.
Puji, Abdulhanin, Febrianto.(2006). Uji Toksisitas Ekstrak Eucheuma alvarezii Terhadap Artemia salina Leach Sebagai Studi Pendahuluan Potensi Antikanker. Akta kimindo, 2(1),41-46.
Ramdhini, N. (2010). Uji Toksisitas Terhadap Artemia salina Leach. Dan Toksisitas Akut Komponen Bioaktif Pandanus conoideus var. ConoideusLam. Sebagai Kandidat Antikanker.Dissertation,Universitas Sebelas Maret,Surakarta.
Ren, Wenying, Zhenhua Qiao, Hongwei Wang, Lei Zhu, and Li Zhang. n.d. (2003). “Flavonoids : Promising AnticancerAgents.†23(4):519–34.
Ridho, E. A., (2013). Uji Aktivitas Antioksidan Ekstrak Metanol Buah Lakum (Cayratia Trifolia) Dengan Metode DPPH. Naskah Publikasi, Program Studi Farmasi, Fakultas Kedoketeran Universitas Tanjung Pura Pontianak.
Sp, Sansevieria, Whika Febria Dewatisari, Leni Rumiyanti, Ismi Rakhmawati, Jl Soekarno, and Hatta No. n.d. (2017). “Rendemen Dan Skrining Fitokimia Pada Ekstrak Daun Sanseviera Sp . Rendemen and Phytochemical Screening Using Leaf Extract Of.†17(3):197–202.
Sukandar.D, Hermanto.S, Lestari.E.(2009). Uji Potensi Antikanker Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Dengan Metode Brine Shrimp Lethality Test (BSLT). Jurnal Kimia Terapan Indonesia,11(1).
Supriningrum, Risa, and Vici Ali Pranamala. (2016). “Uji Toksisitas AkutT Ekstrak Etanol Akar KB (Coptosapelta Tomentosa Valeton Ex K . Heyne) Dengan Metode Brine Shrimp Lethality Test (BSLT).†Jurnal Ilmiah Manuntung 2(2):161–65.
Tapenno, Rb., Tanaka,C., Jie,B., Tapondjou, LA, Miyanto, T. (2016). Trifasciatoside A-J, Steroidal From Sansevieria Trifasciata. Chem Pharm Bull (Tokyo). 2016; 64(9): 1346-55.2.
Yuhernita, Juniarti. (2011). Analisis Senyawa Metabolit Sekunder Dari Ekstrak Metanol Daun Surian Yang Berpotensi Sebagai Antioksidan, Makara Sains, 15(1): 48-52.